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March 8, 2026Scientific ReportsOpen Access

Early fecal metabolomic profiling for predicting acute graft-versus-host disease following allogeneic hematopoietic stem cell transplantation

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Authors

DKDa Jung KimYLYoo Jin LeeJCJung-Won Choi

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Overview

Targeted metabolomic profiling reveals predictive biomarkers for GVHD risk in allo-HSCT recipients, suggesting improved risk assessment strategies.

Key Points

  • This research aims to identify early, noninvasive biomarkers for predicting acute graft-versus-host disease in stem cell transplant recipients.
  • Conducted targeted fecal metabolomic profiling using liquid chromatography–tandem mass spectrometry.
  • Analyzed samples from 77 allo-HSCT recipients at two time points: before conditioning and post-conditioning.
  • Applied multivariate logistic regression and receiver-operating characteristic analysis to evaluate predictive models.
  • Conditioning resulted in significant changes in neurotransmitters, bile acids, and metabolic pathways.
  • Patients developing GVHD exhibited increased xanthine synthesis and altered fatty acid ratios.
  • A panel of 15 metabolites showed moderate predictive ability with an area under the curve of 0.769.

Cite This Study

Kim et al. (2026) studied this question.

synapsesocial.com/papers/69ada836bc08abd80d5bb488https://doi.org/10.1038/s41598-026-38818-8
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