Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 8, 2025BloodOpen Access

A multi-timepoint immune profiling model for differentiating gvhd- and infection-associated diarrhea following allo-HSCT

View Full Paper
Ask AI
Bookmark
Share

Authors

MCMan ChenWZWei ZhaoHWHui Wang

Discussion

Loading...

Member takes

Overview

Retrospective analysis shows immune profiling predicts diarrhea cause in patients post-allo-HSCT, highlighting GVHD and infection.

Key Points

  • To differentiate between graft-versus-host disease and infection-associated diarrhea following allo-HSCT using immune profiling.
  • Retrospective analysis of 58 patients with post-HSCT diarrhea undergoing endoscopic evaluation and biopsy.
  • Monitoring of lymphocyte subsets and cytokines weekly starting from white blood cell engraftment.
  • Development of a predictive model utilizing cytokine and immunophenotypic data.
  • Diarrhea onset was earlier and lasted longer in GVHD than in infection.
  • The predictive model achieved an AUC of 0.908, indicating strong accuracy.
  • Higher levels of Reg3α and specific T cell subsets were found in the GVHD group.

Cite This Study

Chen et al. (2025) studied this question.

synapsesocial.com/papers/69362f694fa91c937236deffhttps://doi.org/10.1182/blood-2025-4231
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Dynamic immune profiling enables early distinction between gastrointestinal GVHD and viral diarrhea after hematopoietic stem cell transplantation2026
  2. 2Pre-transplant Clostridioides difficile infection predicts subsequent gastrointestinal GVHD and non-relapse mortality after allogeneic hematopoietic stem cell transplantation2026
  3. 3Diagnostic prediction of gastrointestinal graft-versus-host disease based on a clinical- CT- signs nomogram model2024 · 3 citations
  4. 4Early fecal metabolomic profiling for predicting acute graft-versus-host disease following allogeneic hematopoietic stem cell transplantation2026
  5. 5Microbiome and cytokine features are associated with graft-versus-host disease incidence in allogeneic hematopoietic cell transplantation patients2025