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December 8, 2025Blood

Paquinimod regulate megakaryocyte function by restoring mitochondrial oxidative phosphorylation in acute myeloid leukemia

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Authors

JHJing-Li HanJZJianying ZhouXZXiaohui Zhang

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Overview

Findings show Paquinimod improves mitochondrial function in megakaryocytes, reducing thrombocytopenia in acute myeloid leukemia.

Key Points

  • To explore how S100a8/a9 influences megakaryocyte apoptosis and mitochondrial function in acute myeloid leukemia.
  • Isolated megakaryocytes from AML patients for RNA-seq analysis.
  • Established an AML model in C57BL/6J mice via injection of C1498 cells.
  • Utilized ELISA to measure S100a8/a9 levels in mice and flow cytometry to analyze megakaryocyte characteristics.
  • Assessed mitochondrial content and morphology using electron microscopy.
  • Compared outcomes between treatments with cytarabine alone and cytarabine plus Paquinimod.
  • RNA-seq showed upregulation of MAPK and Toll-like receptor pathways in AML megakaryocytes.
  • Mitochondrial content decreased, and apoptosis increased in megakaryocytes exposed to S100a8/a9.
  • Paquinimod in combination with cytarabine increased megakaryocyte survival and restored mitochondrial function, improving platelet counts.

Cite This Study

Han et al. (2025) studied this question.

synapsesocial.com/papers/69362f694fa91c937236df23https://doi.org/10.1182/blood-2025-3021
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Interleukin-8 inhibition by reparixin protects megakaryocytes and alleviates thrombocytopenia in Acute Myeloid Leukemia2025
  2. 2Pediatric Acute Myeloid Leukemia associated S100A9 promotes T cell dysfunction2025
  3. 3Disrupting the PA2G4-NPM1 axis induces nucleolar stress in NPM1c AML2025
  4. 4Targeting mitochondrial calcium homeostasis via novel S100A9 inhibitor B2 as a promising agent against AML2026
  5. 5Neutrophil-derived S100A8/A9 impairs megakaryocyte maturation in immune thrombocytopenia2026 · 1 citations