What type of study is this?

This is a In Vitro Study study.

What question did this study set out to answer?

The research aims to understand mechanisms of T cell dysfunction in pediatric acute myeloid leukemia (AML).

December 8, 2025BloodOpen Access

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Phenotypic analyses reveal T cell dysfunction in pediatric AML, indicating S100A9 role in myeloid malignancy effects.

The research aims to understand mechanisms of T cell dysfunction in pediatric acute myeloid leukemia (AML).
Performed phenotypic analyses and genome-wide DNA methylation profiling of T cells from pediatric AML patients.
Compared T cell characteristics in AML with those from acute lymphoblastic leukemia (ALL).
Analyzed the impact of S100A9 on T cells, including functional and transcriptional effects.
AML T cells exhibited a more differentiated methylation signature than ALL T cells.
S100A9 was identified as a key inflammatory factor driving T cell dysfunction.
Increased methylation in genes related to T cell function was observed in AML T cells.

You et al. (2025) studied this question.

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