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December 8, 2025Blood

Endothelial SRSF1 regulates hematopoietic stem cell function in the bone marrow microenvironment

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Authors

KBKruti BosmiaCCCody Carter

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Overview

Conditional knockout of SRSF1 in endothelial cells reveals altered hematopoietic outcomes and increased extramedullary hematopoiesis.

Key Points

  • This study aims to explore the effects of endothelial SRSF1 on hematopoietic stem cell function in the bone marrow microenvironment.
  • Utilized conditional murine model with EC-specific deletion of Srsf1
  • Assessed hematopoietic parameters in Srsf1iECKO mice
  • Conducted competitive transplantation assays for HSC activity
  • Evaluated vascular permeability and blood pressure parameters using modified assay techniques
  • Srsf1iECKO mice exhibited increased white blood cell counts and decreased red blood cells and platelets
  • Observed a significant decrease in hematopoietic engraftment in Srsf1iECKO mice
  • Increased frequency of circulating stem cells in peripheral blood
  • No significant changes in vascular permeability or blood pressure observed

Cite This Study

Bosmia et al. (2025) studied this question.

synapsesocial.com/papers/69362f694fa91c937236df71https://doi.org/10.1182/blood-2025-4966
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