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October 9, 2025Circulation Research

Abstract Thu111: The splicing factor SF3B1 in regulating endothelial gene expression and angiogenesis

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Authors

ZLZiqing Liu

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Overview

This study demonstrates that SF3B1 regulates angiogenesis in endothelial cells, indicating its critical role in gene expression.

Key Points

  • SF3B1 is essential for EC proliferation and survival, underpinning regulatory roles in angiogenesis.
  • Knocking down SF3B1 resulted in disrupted angiogenesis and mis-splicing of over 30% of the transcriptome.
  • Using a new Sf3b1 floxed mouse line, impaired angiogenesis was observed in EC-specific knockout (iECKO) during development.
  • Analysis highlighted the need for consideration of vascular toxicity in therapies targeting splicing factors like SF3B1.

Cite This Study

Ziqing Liu (2025) studied this question.

synapsesocial.com/papers/68e80eb363e2e2f707877dc6https://doi.org/10.1161/res.137.suppl_1.thu111
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