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December 8, 2025BloodOpen Access

Transcriptional programming by GATA3 regulates CD4+ T cell GM-CSF production in the gastrointestinal tract during graft versus host disease

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Authors

JFJonathan FlorentinRSRavi K. Shah

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Overview

Gene editing reveals GATA3's critical role in GM-CSF production by CD4+ T cells in the gastrointestinal tract during graft versus host disease, influencing inflammation and outcomes.

Key Points

  • This research examines the role of GATA3 in regulating GM-CSF production in CD4+ T cells during graft versus host disease.
  • Utilized major histocompatibility mismatched murine GVHD model
  • Conducted single cell RNA sequencing on T cells from the gastrointestinal tract
  • Employed CRISPR Cas9-mediated gene editing to analyze GATA3 function
  • GATA3 deletion increased lethality and inflammation in GVHD
  • CD4+ T cells lacking GATA3 showed reduced GM-CSF expression
  • Increased serum levels of IFN-γ and IL-17 were observed in GATA3-deficient mice

Cite This Study

Florentin et al. (2025) studied this question.

synapsesocial.com/papers/69362f6c4fa91c937236dfb2https://doi.org/10.1182/blood-2025-158
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1GATA3 expressing CD4 T cells promote intestinal graft-versus-host disease 23068182026
  2. 2Galectin-3 in host murine models lessens the severity of graft-versus-host disease by preserving intestinal stem cells irrespective of gut microbiota composition2025
  3. 3Overexpression of CD103 on regulatory T cells mitigates acute graft-versus-host disease via promotion of tolerogenic dendritic cell networks2025 · 1 citations
  4. 4IFNγ-driven MHC class II expression by intestinal epithelial cells dictates local cytolytic Th1 cell differentiation and intestinal stem cell loss2025
  5. 5Abstract A043: Single-cell and bulk transcriptomics uncovers GATA3-mediated macrophage immunosuppressive programming in murine and human cancers2026