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December 8, 2025Blood

Overexpression of CD103 on regulatory T cells mitigates acute graft-versus-host disease via promotion of tolerogenic dendritic cell networks

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Authors

MTMehrdad Hefazi TorghabehOSOlivia SirpillaJFJennifer M. Feigin

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Overview

Graft-versus-host disease mitigation and increased survival in mice with CD103+ Tregs indicate crucial immune modulation.

Key Points

  • To explore the effects of CD103 overexpression on Tregs in mitigating graft-versus-host disease (GVHD).
  • Murine CD4 Tregs transduced with CD103 evaluated in acute GVHD model
  • Flow cytometry, multiplex cytokine assays, and single-cell RNA sequencing used for analysis
  • Ex vivo expanded Tregs assessed for metabolic activities using glucose tracing assays
  • CD103high Tregs showed improved in vitro suppression and proliferation compared to control Tregs
  • In vivo, CD103high Tregs significantly reduced GVHD severity and improved survival rates
  • Increased IL-10 levels and altered immune cell communication demonstrated immunoregulatory effects

Cite This Study

Torghabeh et al. (2025) studied this question.

synapsesocial.com/papers/69362f514fa91c937236d956https://doi.org/10.1182/blood-2025-587
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