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December 8, 2025Blood

Galectin-3 in host murine models lessens the severity of graft-versus-host disease by preserving intestinal stem cells irrespective of gut microbiota composition

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Authors

NNNour NassourEGEduardo Cortes GomezJWJianmin Wang

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Overview

Murine models demonstrate that Galectin-3 reduces graft-versus-host disease severity, suggesting microbiome impact is secondary.

Key Points

  • This research examines Galectin-3's role in regulating gut health and mitigating graft-versus-host disease during allo-HCT.
  • Utilized murine allo-HCT models including Gal-3 depleted and wild-type mice.
  • Conducted weight monitoring, survival analysis, and microbiome analysis post-transplantation.
  • Applied flow cytometry for cytokine analysis and multicolor immunofluorescence for intestinal cell markers.
  • Gal-3 depleted mice exhibited reduced survival compared to wild-type mice post allo-HCT.
  • Distinct microbiome profiles were observed in Gal-3 negative compared to wild-type mice.
  • Conditional Gal-3 knockout in intestinal stem cells led to significantly higher mortality rates.

Cite This Study

Nassour et al. (2025) studied this question.

synapsesocial.com/papers/69362f574fa91c937236daadhttps://doi.org/10.1182/blood-2025-4083
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