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December 8, 2025BloodOpen Access

Ornithine decarboxylase deficiency in donor T cells preserves strong GVL activity while attenuating acute and preventing steroid-resistant gut GVHD in a recipient tissue PD-L1-dependent manner

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Authors

MZMoqian ZhengXWXiwei WuRNRyotaro Nakamura

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Overview

Murine Allo-HCT shows that ODC deficiency enhances GVL activity while preventing steroid-resistant gut GVHD via PD-L1.

Key Points

  • This research investigates the role of ornithine decarboxylase deficiency in donor T cells during allogeneic hematopoietic cell transplantation.
  • Utilized a murine model of Allo-HCT with C57BL/6 donors and BALB/c recipients.
  • Measured GVL activity by administering Luc+/ALL and using in vivo bioluminescent imaging.
  • Administered dexamethasone treatment to assess its effects on GVHD and GVL activity.
  • ODC deficiency in donor T cells preserved GVL activity while significantly reducing gut GVHD severity.
  • Dexamethasone treatment attenuated GVHD in ODC-deficient donor T cells while preserving GVL effects.
  • Survival exceeded 100 days in recipients of ODC-deficient T cells without detectable tumors or GVHD.

Cite This Study

Zheng et al. (2025) studied this question.

synapsesocial.com/papers/69362f744fa91c937236e28ahttps://doi.org/10.1182/blood-2025-5868
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Also Consider

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  1. 1Monocarboxylate transporter 1 deficient donor T cells rewire metabolism and ameliorate aGVHD lethality2025
  2. 2Targeting donor XCR1+ and CD11b+ dendritic cells prevents Th1 and Th17-dependent GVHD within the Gastrointestinal Tract.2026 · 3 citations
  3. 3Peroxisome proliferator-activated receptor delta loss reduces alloreactive CD4 T cell proliferation and lessens graft-versus-host-disease severity 22603482026
  4. 4Development of a Protective Cellular Therapy to Prevent Graft Versus Host Disease Post Allogenic Hematopoietic Stem Cell Transplant 23319392026
  5. 5Recipient Endothelial IRF1 mediates IFNγ-driven tissue tolerance in mouse models of acute Graft-versus-Host Disease.2026