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December 8, 2025BloodOpen Access

Control of gvhd by probiotics with a single strain of muribaculaceae bacterium through secretory proteins

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Authors

LTLinlu TianXYXiaohong YuanAPAllison Pugel

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Overview

Administration of probiotics improved gut microbiota diversity and reduced GVHD in mice, indicating potential therapeutic applications.

Key Points

  • To evaluate the effects of Muribaculaceae bacterium on GVHD and tumor relapse in murine HCT models.
  • Utilized multiple murine allo-BMT models with leukemia
  • Monitored GVHD severity through survival and clinical scores
  • Measured host microbiota changes by 16S rRNA sequencing
  • Assessed cytokine levels and intestinal integrity after probiotic administration
  • Probiotic treatment improved survival and reduced GVHD clinical scores
  • Enhanced gut microbiota diversity was observed with Muribaculaceae administration
  • Probiotic effects reliant on live bacteria, showing diminished efficacy with heat-killed strains
  • Administering probiotics also attenuated GVHD in antibiotic-treated or germ-free mice, albeit less effectively.

Cite This Study

Tian et al. (2025) studied this question.

synapsesocial.com/papers/69362f694fa91c937236df01https://doi.org/10.1182/blood-2025-4234
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Abstract 2868: MaaT013 pooled fecal microbiotherapy improves gastrointestinal physiology and controls inflammation which delays GvHD in a proof-of-concept humanized mouse study2026
  2. 2Multi-omics analysis of a fecal microbiota transplantation trial identifies novel aspects of acute graft-versus-host disease pathogenesis2024 · 14 citations
  3. 3MaaT013 fecal microbiotherapy modulates key gastro-intestinal and immunological processes involved in GvHD pathogenesis in vitro and in vivo2026
  4. 4Microbiome and cytokine features are associated with graft-versus-host disease incidence in allogeneic hematopoietic cell transplantation patients2025
  5. 5Data from Multi-omics Analysis of a Fecal Microbiota Transplantation Trial Identifies Novel Aspects of Acute GVHD Pathogenesis2024