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December 8, 2025BloodOpen Access

Enteral supplementation with a TGF-β-enriched polymeric diet mitigates gastrointestinal acute gvhd

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Authors

SCSubhendra ChatterjeeLRLucia RieglerVWValentin Wenger

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Overview

Pilot clinical study shows improved metabolic profiles in GI-aGVHD patients, suggesting nutritional interventions may reduce inflammation and enhance immune regulation.

Key Points

  • This research aims to evaluate the efficacy of a TGF-β-enriched polymeric diet in mitigating gastrointestinal acute graft-versus-host disease during allo-HCT.
  • Pilot clinical study involving allo-HCT recipients receiving Modulen® IBD
  • Serum samples analyzed via liquid chromatography-mass spectrometry for fatty acids and metabolites
  • Pre-clinical murine model assessing histological aGVHD scores and immune responses
  • Increased anti-inflammatory long-chain fatty acids observed in serum
  • Reduced pro-inflammatory lipids and GVHD-associated amino acids in mice
  • Enhanced IL-10 production and reduced T cell infiltration in colon and brain

Cite This Study

Chatterjee et al. (2025) studied this question.

synapsesocial.com/papers/69362f574fa91c937236dab2https://doi.org/10.1182/blood-2025-4081
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Modulation of Gut Microbiota Through Dietary Fibers to Enhance Regulatory T Cell-Based Immunotherapy in GVHD Following Hematopoietic Stem Cell Transplantation2026 · 3 citations
  2. 2Gut microbiota recovery via butyrate supplementation prevents acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation2025
  3. 3Dietary fiber intake improves survival in allogeneic HCT patients and exhibits synergistic effects with taurine supplementation in preclinical models2025
  4. 4MaaT013 fecal microbiotherapy modulates key gastro-intestinal and immunological processes involved in GvHD pathogenesis in vitro and in vivo2026
  5. 5Abstract 2794: Consumption of dietary fiber correlates with a significant increase in a-diversity in the intestinal Microbiome of allo-HCT recipients and with lower GVHD-lethality in pre-clinical models2024 · 1 citations