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December 8, 2025BloodOpen Access

Dietary fiber intake improves survival in allogeneic HCT patients and exhibits synergistic effects with taurine supplementation in preclinical models

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Authors

JPJenny ParedesCEColt A. EgelstonOFOscar Colunga Flores

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Overview

Observational study associates dietary fiber with improved survival and reduced aGVHD in patients, suggesting microbiome modulation may enhance outcomes.

Key Points

  • This research assesses the impact of dietary fiber intake on survival and disease incidence post-allogeneic HCT.
  • Analyzed dietary patterns in 173 allo-HCT patients over 3,837 patient-days.
  • Conducted preclinical studies using a C57BL/6J-to-BALB/c GVHD mouse model with varying cellulose diets.
  • Performed microbial and biochemical analyses to evaluate fiber and taurine effects on GVHD.
  • Pre-transplant fiber intake correlates with improved survival and reduced aGVHD.
  • A 12% cellulose diet in mice reduces GVHD lethality and enhances microbial diversity.
  • Taurine supplementation improves survival in GVHD models and combines synergistically with dietary cellulose.

Cite This Study

Paredes et al. (2025) studied this question.

synapsesocial.com/papers/69362f744fa91c937236e289https://doi.org/10.1182/blood-2025-5869
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Abstract 2794: Consumption of dietary fiber correlates with a significant increase in a-diversity in the intestinal Microbiome of allo-HCT recipients and with lower GVHD-lethality in pre-clinical models2024 · 1 citations
  2. 2Modulation of Gut Microbiota Through Dietary Fibers to Enhance Regulatory T Cell-Based Immunotherapy in GVHD Following Hematopoietic Stem Cell Transplantation2026 · 3 citations
  3. 3Enteral supplementation with a TGF-β-enriched polymeric diet mitigates gastrointestinal acute gvhd2025
  4. 4Gut microbiota recovery via butyrate supplementation prevents acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation2025
  5. 5Poor nutritional intake prior to allogeneic hematopoietic cell transplantation is associated with higher incidence of lower-gastrointestinal graft-versus-host disease2025