Poor nutritional intake prior to allogeneic hematopoietic cell transplantation is associated with higher incidence of lower-gastrointestinal graft-versus-host disease
Pilot trial shows low calorie and protein intake linked to higher GI graft-versus-host disease in transplant patients, suggesting nutritional intervention may help.
Key Points
To investigate the relationship between nutritional intake and the incidence of lower gastrointestinal graft-versus-host disease after allogeneic hematopoietic cell transplantation.
Evaluated dietary intake from 30 patients during and post-allo-HCT
Administered Clostridium butyricum MIYAIRI 588 in a pilot trial
Collected stool samples and performed microbiome sequencing to assess composition
Conducted statistical analyses including Kaplan Meier and Cox proportional hazard ratio
Most patients had calorie intake below estimated energy requirements during allo-HCT
Lower GI graft-versus-host disease was associated with inadequate baseline calorie and protein intake
Patients consuming >50% protein needs had differences in intestinal microbiota composition