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December 8, 2025BloodOpen Access

Gut microbiota recovery via butyrate supplementation prevents acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation

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Authors

JWJong-Ho Won

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Overview

Prospective trial shows oral butyrate reduces acute graft-versus-host disease in hematopoietic stem cell transplant patients, suggesting gut microbiota plays a protective role.

Key Points

  • Assess butyrate supplementation effects on gut microbiota and acute graft-versus-host disease in hematopoietic stem cell transplant patients.
  • Prospective study with 39 patients receiving sodium butyrate post-allogeneic transplantation.
  • Control group of 18 historical patients without butyrate supplementation.
  • Stool samples collected pre-transplant, during engraftment, and at day +100 for microbial analysis.
  • Lower cumulative incidence of acute graft-versus-host disease in the butyrate group compared to control.
  • Markedly reduced lower gastrointestinal GVHD incidence in the butyrate group (5.13%) versus control (40.42%).
  • Higher gut microbiota diversity recovery post-transplant in the butyrate group.

Cite This Study

Jong-Ho Won (2025) studied this question.

synapsesocial.com/papers/69362f694fa91c937236def3https://doi.org/10.1182/blood-2025-4226
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Gentamicin alleviates intestinal graft-versus-host disease by modulating butyrate-associated gut microbiota2025
  2. 2Microbiome Signature Linked to the Development and Management of Intestinal Acute Graft-versus-Host Disease in Pediatric Patients Undergoing Hematopoietic Stem Cell Transplantation2025
  3. 3Alterations in the gut microbiome and the association of butyrate producers with progression-free survival in multiple myeloma patients undergoing autologous stem cell transplantation2025
  4. 4Early gut microbiome metabolites and diversity predict GVHD-free survival after allogeneic hematopoietic cell transplantation2026
  5. 5Clostridium butyricum MIYAIRI 588 contributes to the maintenance of intestinal microbiota diversity early after haematopoietic cell transplantation2024 · 13 citations