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December 8, 2025Blood

Alterations in the gut microbiome and the association of butyrate producers with progression-free survival in multiple myeloma patients undergoing autologous stem cell transplantation

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Authors

AAAdolfo AlemanAKAditya Kasina

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Overview

Observational study shows loss of butyrate producers worsens progression-free survival in multiple myeloma, suggesting microbiome as a therapeutic target.

Key Points

  • To investigate the association between gut microbiome alterations and progression-free survival in multiple myeloma patients undergoing autologous stem cell transplantation.
  • Analyzed gut microbiome via 16S rRNA sequencing in 64 newly diagnosed multiple myeloma patients.
  • Used Random Forest predictor to identify taxa linked to late relapse.
  • Employed Multivariate Cox regression model to assess correlations between taxa and progression-free survival.
  • Depletion of butyrate-producing bacteria correlates with worse progression-free survival at engraftment.
  • Higher abundance of specific butyrate producers linked to better outcomes in multiple myeloma patients.
  • Butyrate treatment reduced tumor burden by 95% in the 5TGM1 model.

Cite This Study

Aleman et al. (2025) studied this question.

synapsesocial.com/papers/69362f514fa91c937236d95bhttps://doi.org/10.1182/blood-2025-575
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Gut microbiota recovery via butyrate supplementation prevents acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation2025
  2. 2Data from Short-Chain Fatty Acid Production by Gut Microbiota Predicts Treatment Response in Multiple Myeloma2024
  3. 3The Potential of the Gut Microbiota and Butyrate to Enhance CAR-T Cell Therapy in Non-Hodgkin Lymphoma2025
  4. 4Abstract 6881: Investigating the role of post-transplant bone marrow immune dysregulation in multiple myeloma2024
  5. 5Gut microbiota regulates acute myeloid leukaemia via alteration of intestinal barrier function mediated by butyrate2022 · 221 citations