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December 8, 2025Blood

Clinical characteristics and outcomes in patients with SH2B3-mutated erythrocytosis: A retrospective cohort study

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Authors

AMAidan McKeeJHJenny HoBSBekim Sadiković

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Overview

Retrospective cohort study describes SH2B3-mutated erythrocytosis, revealing low thrombotic risk and treatment profiles.

Key Points

  • To characterize clinical characteristics and outcomes of patients with SH2B3-mutated erythrocytosis compared to other forms of erythrocytosis.
  • Retrospective cohort study conducted at a tertiary center
  • Adult patients evaluated for erythrocytosis with myeloid next generation sequencing
  • Comparison between SH2B3-mutated erythrocytosis, JAK2-mutated PV, and secondary erythrocytosis
  • Identified 16 patients with SH2B3-mutated erythrocytosis, 103 with PV, and 566 with secondary erythrocytosis
  • Median age for SH2B3-mutated erythrocytosis was 59 years, similar to secondary erythrocytosis
  • Observed one case of venous thrombosis in SH2B3-mutated group with no arterial thrombotic events

Cite This Study

McKee et al. (2025) studied this question.

synapsesocial.com/papers/69362f6c4fa91c937236dfcehttps://doi.org/10.1182/blood-2025-7317
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