Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 8, 2025BloodOpen Access

The presence of SH2B3 mutations identifies a distinct subtype of myelodysplastic neoplasms

View Full Paper
Ask AI
Bookmark
Share

Authors

PAPamela AchaNANajla Al AliAMAlain Migeon

Discussion

Loading...

Member takes

Overview

Analysis shows sh2b3 mutations influence prognostic impact and clinical features in myelodysplastic neoplasms.

Key Points

  • To analyze the prognostic impact and clinical features of sh2b3 mutations in myelodysplastic neoplasms.
  • Included myelodysplastic neoplasm patients with sh2b3 mutations from 19 centers
  • Compared clinical data and outcomes between sh2b3mut and sh2b3wt patients
  • Utilized IPSS-R and IPSS-M for risk assessment
  • Sh2b3mut patients exhibited better overall survival compared to sh2b3wt patients
  • Significant age difference: sh2b3mut patients median age was 74 years
  • Higher mutation rates in TET2 and SRSF2 observed in sh2b3mut patients

Cite This Study

Acha et al. (2025) studied this question.

synapsesocial.com/papers/69362f4b4fa91c937236d797https://doi.org/10.1182/blood-2025-2070
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1<i>SH2B3</i> in myeloid neoplasms: Potential pathogenic role of variants of uncertain significance.2026
  2. 2Clinical characteristics and molecular profiling of SF3B1-mutated myelodysplastic syndrome (MDS) in a real-world practice2025
  3. 3Clinical characteristics and outcomes in patients with SH2B3-mutated erythrocytosis: A retrospective cohort study2025
  4. 4Prognostic impact of &lt;i&gt;SF3B1&lt;/i&gt; mutation and multilineage dysplasia in myelodysplastic syndromes with ring sideroblasts: a Mayo Clinic study of 170 informative cases2024 · 1 citations
  5. 5Germline variant database and visualization platform for BMF and hematologic malignancy predisposition syndromes: BMFgenes1.02025