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December 8, 2025Blood

The growing burden of high body mass index associated hematological cancer mortality in the United States of America (USA): A 30-year analysis (1990–2021)

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Authors

RKRupayan KunduSMSudipto Mukherjee

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Overview

This analysis reveals increasing mortality from hematological cancer in the USA associated with high obesity rates, highlighting urgent health concerns.

Key Points

  • To examine the burden of high BMI-related hematological cancer deaths in the USA from 1990 to 2021.
  • Analyzed data from the Global Health Data Exchange 2021 database
  • Calculated population attributable fractions to estimate neoplasm deaths related to high BMI
  • Tracked mortality trends using annual percentage change
  • In 2021, high BMI accounted for approximately 3,848 deaths from leukemia
  • The percentage of deaths from high BMI increased significantly for multiple myeloma (34.40%), leukemia (28.22%), and non-Hodgkin lymphoma (32.80%)
  • Notable geographic disparities were observed, with variations across U.S. states

Cite This Study

Kundu et al. (2025) studied this question.

synapsesocial.com/papers/69362f6c4fa91c937236dfd3https://doi.org/10.1182/blood-2025-6835
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Comparative epidemiological analysis of hematological malignancies in adolescents and young adults (AYA) in the United States of America (USA), 1990–2021, with projections to 20402025
  2. 2The impact of high body-mass index on cancer mortality in the United States: An emerging public health challenge.2026
  3. 3Global burden and trends of leukemia attributable to high body mass index risk in adults over the past 30 years2024 · 5 citations
  4. 4Divergent trends in high BMI-associated NHL mortality: An analysis of the globalburden of disease database 1990-20212025
  5. 5Rising burden and deepening inequalities: a national study of high BMI-related uterine cancer in the United States using GBD and NHANES data2026