Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 8, 2025Blood

Clinical and biological impact of plasma cytokine levels in newly diagnosed chronic lymphocytic leukemia

View Full Paper
Ask AI
Bookmark
Share

Authors

CCChiara CosentinoNMNawar MaherCDClara Deambrogi

Discussion

Loading...

Member takes

Overview

Analysis shows cytokine levels correlate with survival and disease features in chronic lymphocytic leukemia, indicating clinical implications.

Key Points

  • This research aims to explore the relationship between plasma cytokine levels and clinical outcomes in patients with chronic lymphocytic leukemia.
  • Analyzed plasma from newly diagnosed CLL patients using a 27-plex enzymatic assay.
  • Defined cut-offs for overall survival, Richter transformation probability, and second malignancy risk utilizing selected ranking statistics.
  • Applied machine-learning algorithms, including self-organizing map and K-means, for patient clustering based on cytokine levels.
  • Elevated MIP-1α and IL-4 levels significantly associated with unmutated IGHV genes and poor overall survival.
  • Patients were grouped into distinct clusters based on cytokine profiles, impacting overall survival outcomes.
  • High levels of GM-CSF predicted increased risk of Richter transformation and shorter time to second malignancies.

Cite This Study

Cosentino et al. (2025) studied this question.

synapsesocial.com/papers/69362f6c4fa91c937236dfd8https://doi.org/10.1182/blood-2025-7404
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A-166 Role of Interleukins (2, 6, 10) and Serum Beta-2 Microglobulin (Sß2M) in Chronic Lymphocytic Leukemia2025
  2. 2Assessment and prognostic significance of a serum cytokine panel in diffuse large B‑cell lymphoma2024 · 6 citations
  3. 3Elevated interleukin-10 at diagnosis and during treatment independently predicts adverse outcomes in angioimmunoblastic T-cell lymphoma2025
  4. 4Abstract PS4-01-24: Cytokine score based on expression levels of multiple cytokines is a prognostic indicator in metastatic breast cancer patients treated with chemotherapy2026
  5. 5Soluble cytokines enhance risk prediction across all stages of classical Hodgkin lymphoma2026