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December 8, 2025BloodOpen Access

Elevated interleukin-10 at diagnosis and during treatment independently predicts adverse outcomes in angioimmunoblastic T-cell lymphoma

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Authors

YZYi ZhaoLZLixia ZhuLHLinlin Huang

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Overview

Retrospective analysis reveals high IL-10 and IL-6 levels are linked to poor survival and treatment response in AITL.

Key Points

  • This study investigates the relationship between cytokine levels and clinical outcomes in angioimmunoblastic T-cell lymphoma (AITL).
  • Multicenter, retrospective study involving newly diagnosed adult patients with AITL
  • Analyzed serum levels of seven cytokines at diagnosis and various timepoints
  • Determined optimal cutoff values for overall survival using maximally selected rank statistics
  • 267 patients showed high-risk features including advanced-stage disease and poor prognostic scores
  • Elevated IL-6 and IL-10 are associated with adverse clinical features and shorter median overall survival
  • High IL-10 levels independently predict poorer outcomes, highlighting its role as a prognostic factor

Cite This Study

Zhao et al. (2025) studied this question.

synapsesocial.com/papers/69362f714fa91c937236e1e7https://doi.org/10.1182/blood-2025-3645
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Serum interleukin-10 and clinical outcomes in primary gastrointestinal lymphoma: a retrospective cohort study2026
  2. 2Clinical and biological impact of plasma cytokine levels in newly diagnosed chronic lymphocytic leukemia2025
  3. 3The addition of EBV and C3 complement risk factors formed a better angioimmunoblastic T-cell lymphoma prognostic scoring system2025
  4. 4Real-world study and prognostic analysis of angioimmunoblastic T-cell lymphoma2024 · 2 citations
  5. 5Clinicopathological Characteristics and Prognostic Factors in Angioimmunoblastic T-cell Lymphoma: a Retrospective Analysis2026