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December 8, 2025BloodOpen Access

The addition of EBV and C3 complement risk factors formed a better angioimmunoblastic T-cell lymphoma prognostic scoring system

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Authors

FYFang YuYZYi ZhaoLHLinlin Huang

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Overview

Retrospective analysis improves prognosis score and demonstrates distinct survival in angioimmunoblastic T-cell lymphoma patients.

Key Points

  • This research aims to develop a new prognostic scoring system for angioimmunoblastic T-cell lymphoma, integrating EBV and C3 factors.
  • Conducted a retrospective multicenter analysis of 350 AITL patients across 4 medical centers.
  • Utilized LASSO regression to identify risk factors for progression-free survival and overall survival.
  • Employed ROC analysis for developing and verifying predictive models based on identified factors.
  • Identified multiple prognostic factors including age, ECOG score, and EBV copy number.
  • Developed AITL-HZ scoring system that predicts patient outcomes with improved accuracy.
  • Comparison with existing scoring systems showed AITL-HZ had significantly higher predictive capability for PFS and OS.

Cite This Study

Yu et al. (2025) studied this question.

synapsesocial.com/papers/69362f484fa91c937236d727https://doi.org/10.1182/blood-2025-7148
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Real-world study and prognostic analysis of angioimmunoblastic T-cell lymphoma2024 · 2 citations
  2. 2Real-World Data on Clinical Outcomes and Validation of Prognostic Models for Angioimmunoblastic T-cell Lymphoma: A Multicentric Retrospective Study in Southern China2024
  3. 3Prognostic role of whole blood Epstein‑Barr virus DNA load in angioimmunoblastic T-cell lymphoma2026
  4. 4Deciphering tph cells as prognostic drivers of angioimmunoblastic T-cell lymphoma2025
  5. 5Elevated interleukin-10 at diagnosis and during treatment independently predicts adverse outcomes in angioimmunoblastic T-cell lymphoma2025