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October 14, 2024Frontiers in ImmunologyOpen Access

Real-world study and prognostic analysis of angioimmunoblastic T-cell lymphoma

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Authors

SLSuxiao LiXFXiaoyan FengYSYunfei Song

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Overview

Retrospective analysis of prognostic factors and treatments for angioimmunoblastic T-cell lymphoma, indicating a need for optimized therapy.

Key Points

  • To analyze clinical prognostic factors and develop a prognostic model for angioimmunoblastic T-cell lymphoma.
  • Retrospective analysis of 231 patients with AITL from January 2014 to July 2023.
  • Primary endpoints were overall survival (OS) and progression-free survival (PFS).
  • Multivariate analysis identified key prognostic factors affecting OS.
  • Median OS was 17 months and median PFS was 6 months.
  • Age >60 years, ECOG status ≥2, elevated LDH, and splenomegaly were linked to inferior OS.
  • The novel AITL prognostic model stratified patients into low-, intermediate-, and high-risk groups with 2-year OS estimates of 63.6%, 42.1%, and 18.6%, respectively.

Cite This Study

Li et al. (2024) studied this question.

synapsesocial.com/papers/6a6a8d912ef98b0efacb2d57https://doi.org/10.3389/fimmu.2024.1481301
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  4. 4Clinicopathological Characteristics and Prognostic Factors in Angioimmunoblastic T-cell Lymphoma: a Retrospective Analysis2026
  5. 5Autologous stem cell transplantation and real-world outcomes in angioimmunoblastic T-cell lymphoma: A national cohort study2025