What question did this study set out to answer?

To examine differences in immune profiles between patients with light-chain and transthyretin amyloidosis.

December 8, 2025Blood

Circulating immune profile in patients with amyloidosis

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Immune profiles differ in patients with light-chain and transthyretin amyloidosis, indicating activation and potential lymphocyte exhaustion.

To examine differences in immune profiles between patients with light-chain and transthyretin amyloidosis.
Flow cytometry assessed peripheral blood lymphocyte populations in amyloidosis patients.
Comparative analysis of treatment-naïve AL and ATTR patients against healthy donors and negative patients.
Statistical analyses included regression models controlling for age, sex, and diagnosis.
Patients with amyloidosis exhibit an activated, exhausted lymphocyte profile compared to negative controls.
Compared to healthy donors, amyloidosis patients show reduced naïve T cells and increased terminally differentiated lymphocytes.
Differences in immune markers were noted but often not significant after FDR correction.

Tario et al. (2025) studied this question.

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Immune profiles differ in patients with light-chain and transthyretin amyloidosis, indicating activation and potential lymphocyte exhaustion.