September 23, 2025Journal of Cellular and Molecular MedicineOpen Access

Molecular Expression Differences in Specific Blood Mononuclear Cell‐Types Identify Patients With AL Amyloidosis

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Authors

DKDavid R. KaplanUniversity of British Columbia ECEric ChristianGLC Biotechnology (United States)JVJason ValentCleveland Clinic

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Implication

Enhanced flow cytometric analysis identifies diagnostic biomarkers in mononuclear cells of AL amyloidosis patients, suggesting new avenues for detection.

Key Points

Diagnostic assays may improve with mononuclear cell-type specific molecular expression, highlighting its potential.
In CD4 + T cells, BDNF expression levels distinguish AL amyloidosis from myeloma with AUC = 0.75.
This approach relies on enhanced flow cytometric analysis of blood monocytes and CD4 + T cells, exploring key analytes.
Findings suggest specific pathogenetic pathways involved in AL amyloidosis, calling for further studies.

Cite This Study

Kaplan et al. (2025) studied this question.

synapsesocial.com/papers/68d4724731b076d99fa6ab2a https://doi.org/10.1111/jcmm.70850

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Implication

Enhanced flow cytometric analysis identifies diagnostic biomarkers in mononuclear cells of AL amyloidosis patients, suggesting new avenues for detection.

Molecular Expression Differences in Specific Blood Mononuclear Cell‐Types Identify Patients With AL Amyloidosis

Discussion

Member takes

Implication

Key Points

Cite This Study

Molecular Expression Differences in Specific Blood Mononuclear Cell‐Types Identify Patients With AL Amyloidosis

Discussion

Member takes

Implication

Key Points

Cite This Study

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