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This research aims to explore the transcriptomic features of plasma cells in AL amyloidosis and their immune interactions.

December 8, 2025BloodOpen Access

Single-cell transcriptomics of AL amyloidosis reveals pathogenic mechanisms, immune interactions and altered clonal and polyclonal plasma cell phenotypes

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Single-cell transcriptomics reveals immune dysregulation and altered plasma cell phenotypes in AL amyloidosis, suggesting therapeutic targets.

This research aims to explore the transcriptomic features of plasma cells in AL amyloidosis and their immune interactions.
Performed single-cell RNA sequencing on bone marrow aspirates from AL amyloidosis patients and healthy donors.
Conducted differential gene expression analyses comparing malignant to non-malignant plasma cells.
Utilized gene ontology enrichment and cell-cell communication analyses to understand signaling pathways.
Identified significant immune dysregulation and altered gene expression in malignant plasma cells compared to healthy controls.
Detected upregulation of proteostasis-related genes and cytokine regulators within the disease microenvironment.
Highlighted potential therapeutic targets, including GSTP1, demonstrating significant effects in vitro.

Smith et al. (2025) studied this question.

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Single-cell transcriptomics reveals immune dysregulation and altered plasma cell phenotypes in AL amyloidosis, suggesting therapeutic targets.