May 27, 2024Open Access

Genotypic identification of polyclonal plasma cells in plasma cell dyscrasias shows an aberrant single-cell phenotype with clinical implications

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Authors

MVMatteo Da ViàUniversity of Milan FLFrancesca LazzaroniFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico AMAntonio MateraFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico

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Implication

Cohort study reveals aberrant pro-inflammatory phenotypes in residual polyclonal plasma cells in plasma cell dyscrasias, highlighting prognostic relevance for survival.

Key Points

Residual polyclonal plasma cells display an aberrant pro-inflammatory phenotype in multiple myeloma, driven by interactions with the tumor microenvironment.
Genotypic analysis identified 42,717 polyclonal plasma cells out of 213,074 CD138 positive cells, demonstrating disruption in patients with immunoparesis.
Analysis of 46 patient cohorts using single-cell RNA sequencing established a cellular signature, highlighting prognostic value for multiple myeloma survival.

Cite This Study

Vià et al. (2024) studied this question.

synapsesocial.com/papers/68e68498b6db64358760d3af https://doi.org/10.1101/2024.05.26.595470

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Implication

Cohort study reveals aberrant pro-inflammatory phenotypes in residual polyclonal plasma cells in plasma cell dyscrasias, highlighting prognostic relevance for survival.

Genotypic identification of polyclonal plasma cells in plasma cell dyscrasias shows an aberrant single-cell phenotype with clinical implications

Discussion

Member takes

Implication

Key Points

Cite This Study

Genotypic identification of polyclonal plasma cells in plasma cell dyscrasias shows an aberrant single-cell phenotype with clinical implications

Discussion

Member takes

Implication

Key Points

Cite This Study

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