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December 8, 2025BloodOpen Access

IgD-related AL amyloidosis: Clinical features and outcomes

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Authors

TJTracy Joshi

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Overview

Retrospective review identifies treatment responses and organ involvement in patients with IgD-related AL amyloidosis, suggesting a need for tailored therapies.

Key Points

  • To evaluate the clinical features and treatment outcomes of patients with IgD-related AL amyloidosis.
  • Retrospective review of 1,798 patients diagnosed with AL amyloidosis from 2000 to 2024.
  • Collected data on presenting symptoms, organ involvement, biomarker levels, treatments, and outcomes.
  • Responses assessed as per the International Society of Amyloidosis consensus criteria.
  • 11 patients (0.6%) had IgD monoclonal protein among AL amyloidosis cases.
  • 64% showed cardiac involvement; 36% exhibited renal involvement.
  • Hematologic response to first-line therapy was high, with 86% achieving a very good partial response.

Cite This Study

Tracy Joshi (2025) studied this question.

synapsesocial.com/papers/69362f6e4fa91c937236e08bhttps://doi.org/10.1182/blood-2025-7500
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Presenting features, treatment patterns and predictors of outcomes in AL amyloidosis at a tertirary care cancer centre2025
  2. 2[Clinical characteristics analysis of patients with IgD type systemic light chain amyloidosis].2025
  3. 3The clinical features of immunoglobulin light-chain (AL) amyloidosis with heart involvement1998 · 575 citations
  4. 4#2282 Outcomes of renal amyloidosis: 8 years experience of tertiary center2024
  5. 5#2757 Clinical course and prognostic factors in amyloidosis2024