What type of study is this?

This is a Pre-Registered Trial study.

What question did this study set out to answer?

To evaluate the outcomes of minor surgeries in patients with hemophilia A or B receiving fitusiran prophylaxis.

December 8, 2025BloodOpen Access

Experience with minor surgeries in people with hemophilia A or B with and without inhibitors receiving fitusiran

View Full Paper

Ask AI

Bookmark

Authors

CYChur-Woo YouEulji University IHInga HegemannUniversity Hospital of Zurich MTMargarita TimofeevaKirov Research Institute of Hematology and Blood Transfusion FMBA

Discussion

Member takes

Implication

Demonstrates safe surgical outcomes in minor surgeries for hemophilia A and B patients on fitusiran prophylaxis, indicating effective perioperative management.

Key Points

To evaluate the outcomes of minor surgeries in patients with hemophilia A or B receiving fitusiran prophylaxis.
Evaluated minor surgeries in the fitusiran clinical development program until June 2023.
Included surgeries with both original and antithrombin-based dose regimens.
Assessed perioperative hemostatic control using the ISTH 4-point response scale.
95% of minor surgeries achieved excellent/good hemostatic control on the day of surgery.
67% of dental surgeries and 87% of all minor surgeries did not require antifibrinolytics.
No major treatment-related safety concerns were identified during the procedures.

Cite This Study

You et al. (2025) studied this question.

synapsesocial.com/papers/69362f6e4fa91c937236e11a https://doi.org/10.1182/blood-2025-4850

View Full Paper

Ask AI

Bookmark

Implication

Demonstrates safe surgical outcomes in minor surgeries for hemophilia A and B patients on fitusiran prophylaxis, indicating effective perioperative management.

Experience with minor surgeries in people with hemophilia A or B with and without inhibitors receiving fitusiran

Discussion

Member takes

Implication

Key Points

Cite This Study

Experience with minor surgeries in people with hemophilia A or B with and without inhibitors receiving fitusiran

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider