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August 9, 2025

Outcome of Surgical Interventions in Patients with Haemophilia A and B Treated with Extended Half-Life (EHL) Factor Concentrates in a Single Centre.

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Authors

IVInes VaideTartu University HospitalSGS. GottsteinKlinikum im FriedrichshainCKCornelia Kubicek-HofmannKlinikum im Friedrichshain

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Implication

Retrospective review shows safe EHL factor concentrates manage surgical bleeding in haemophilia patients, indicating efficacy in treatment.

Key Points

  • The study assessed 88 surgical interventions in 52 patients with haemophilia A and B using EHL factor concentrates.
  • A total of 11 complications were reported, with 4 classified as bleeding complications during or after surgery.
  • Patients received variable doses of EHL FVIII and FIX before surgery, with median doses around 32 IU/kg for FVIII in major surgeries.
  • No thromboembolic events or new inhibitors were detected during follow-up, confirming the safety of EHL therapy.

Cite This Study

Vaide et al. (2025) studied this question.

synapsesocial.com/papers/689dfe97d61984b91e13c165https://doi.org/10.1055/a-2599-9611
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Also Consider

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  1. 1Surgical wound healing in bleeding disorders2012 · 50 citations
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  4. 4Incidence of deep venous thrombosis in patients with hemophilia undergoing bilateral simultaneous total knee arthroplasty: a retrospective cohort study2024 · 7 citations
  5. 5Using pharmacokinetics to individualize hemophilia therapy2017 · 67 citations