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December 8, 2025Blood

Successful surgical management in severe hemophilia A patients using efanesoctocog alfa: A two-case experience undergoing orthopedic surgery

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Authors

FLFrancisco José López‐JaimePTPatricia Tejuca-GonzalezAMA. Vilariño Mosquera

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Overview

Case report shows successful surgical management in hemophilia A patients using efanesoctocog alfa, indicating clinical efficacy and safety.

Key Points

  • To evaluate efanesoctocog alfa's efficacy, safety, and pharmacokinetics during orthopedic surgery in severe hemophilia A patients.
  • Two male patients with severe hemophilia A underwent elective orthopedic procedures using efanesoctocog alfa.
  • Factor coverage was tailored using FVIII activity levels and clotting assays, with doses given preoperatively and postoperatively.
  • Patients were monitored for bleeding, thrombotic complications, and hemostatic response.
  • Both patients experienced excellent hemostatic response with no bleeding complications during surgeries.
  • Transfusion requirements were completely avoided, and inhibitor development did not occur.
  • Surgeries were completed successfully without significant complications, facilitating early discharge.

Cite This Study

López‐Jaime et al. (2025) studied this question.

synapsesocial.com/papers/69362f4e4fa91c937236d8e8https://doi.org/10.1182/blood-2025-6625
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Perioperative use of efanesoctocog alfa in Hemophilia A: A dual-center real-world study2025
  2. 2Clinical experience with efanesoctocog alfa in patients with uncover needs on emicizumab2025
  3. 3Tailored prophylaxis in severe hemophilia A: Real-world experience with efanesoctocog alfa2025
  4. 4Clinical and Surgical Experiences with Efmoroctocog Alfa in Pediatric Population with Hemophilia A2025
  5. 5Neuraxial Anesthesia in Severe Hemophilia A Using Extended Half-Life Factor VIII (Efanesoctocog Alfa): A Case Report2026