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December 8, 2025Blood

Poor survival and temporal trends in blastic plasmacytoid dendritic cell neoplasm: A SEER 2000–2022 analysis

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Authors

PNPriyanka Nagdev

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Overview

Population analysis reveals poor survival trends in blastic plasmacytoid dendritic cell neoplasm, indicating a need for better treatments.

Key Points

  • To evaluate incidence, treatment patterns, and survival trends for blastic plasmacytoid dendritic cell neoplasm in the US.
  • Analysis of SEER database for BPDCN cases from 2000-2022.
  • Age-adjusted incidence rates calculated using SEER*Stat.
  • Kaplan-Meier analysis for overall survival estimation.
  • Multivariable Cox regression for identifying prognostic factors.
  • Age-adjusted incidence was 0.05 per 100,000, significantly increasing with age.
  • Median overall survival was 25 months with poor survival rates over time.
  • Chemotherapy usage was at 76.6%, with radiation associated with increased mortality (HR 1.67).
  • Demographic disparities in OS were noted among different races, with Asian/Pacific Islanders and Black patients having improved survival.

Cite This Study

Priyanka Nagdev (2025) studied this question.

synapsesocial.com/papers/69362f6e4fa91c937236e154https://doi.org/10.1182/blood-2025-6380
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Also Consider

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  1. 1Real-world study of treatment landscape and safety outcomes of US patients with blastic plasmacytoid dendritic cell neoplasm2025 · 1 citations
  2. 2Real-world conditional survival analysis of blastic plasmacytoid dendritic cell neoplasm.2026
  3. 3Blastic plasmacytoid dendritic cell neoplasm: a Swiss case series of a very rare disease and a structured review of the literature2025
  4. 4Blastic plasmacytoid dendritic cell neoplasm (BPDCN) international registry: Assessment of the allo-HCT outcomes2025 · 1 citations
  5. 5Blastic Plasmacytoid Dendritic Cell Neoplasm: A Dermatological Window for Early Diagnosis2026