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December 8, 2025Blood

More than a bulk: Higher incidence of venous thromboembolism (VTE) in patients with primary mediastinal B-cell lymphoma compared to patients with bulky mediastinal Hodgkin lymphoma

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Authors

LMLuis Fernando de Souza MatosLTLarissa Lane Cardoso TeixeiraCFCarolina Feres

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Overview

Observational analysis found 40% VTE incidence in primary mediastinal B-cell lymphoma, highlighting obesity as a significant risk factor.

Key Points

  • This research aimed to assess the incidence and risk factors of venous thromboembolism (VTE) in primary mediastinal B-cell lymphoma patients.
  • Retrospective analysis of 30 PMBCL patients with complete records
  • Comparison of VTE incidence with bulky mediastinal Hodgkin lymphoma
  • Statistical analyses using Fisher's exact test and Mann-Whitney U test
  • 40% VTE incidence observed in PMBCL, significantly higher than in bulky Hodgkin lymphoma
  • Mean tumor mass diameter in PMBCL was 11.5 cm, with 30% showing SVCS
  • Concomitant factors included obesity in 3 patients and pregnancy in 1 patient

Cite This Study

Matos et al. (2025) studied this question.

synapsesocial.com/papers/69362f714fa91c937236e170https://doi.org/10.1182/blood-2025-1361
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Primary Mediastinal Large B-Cell Lymphoma2004 · 6 citations
  2. 2Clinicopathological Features of Primary Mediastinal Large B-cell Lymphoma: A 5-Year Retrospective Study2026
  3. 3primary mediastinal B-cell lymphoma: Survival trends and statistics2025
  4. 4Massive primary B–cell mediastinal lymphoma with vascular and pulmonary hilum involvement requiring multidisciplinary approach: a case report2026
  5. 5Venous thromboembolism in patients with diffuse large B-cell lymphoma2006 · 84 citations