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December 8, 2025BloodOpen Access

Outcomes of allogeneic hematopoietic cell transplantation in myelofibrosis using post-transplant cyclophosphamide-based gvhd prophylaxis

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Authors

PLPhilip LubanskiThe University of Kansas Health SystemMHMehdi HamadaniMedical College of Wisconsin

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Implication

A multicenter analysis reveals that comorbidity and sex affect outcomes in myelofibrosis after allogeneic transplantation, suggesting enhanced transplant planning is needed.

Key Points

  • This research evaluates post-transplant outcomes for myelofibrosis patients and their association with clinical characteristics.
  • Retrospective multicenter analysis of patients with myelofibrosis undergoing allo-HCT with PTCy (2013-2019)
  • Data sourced from CIBMTR registry
  • Used univariable and multivariable Cox regression models for analysis
  • 216 patients included, OS at 2 years was 59.7%
  • Significant predictors of overall survival included Sorror comorbidity score and prior splenic radiation
  • Female sex linked to increased TRM and reduced risk of cGVHD

Cite This Study

Lubanski et al. (2025) studied this question.

synapsesocial.com/papers/69362f714fa91c937236e19bhttps://doi.org/10.1182/blood-2025-2460
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effect of post-transplant cyclophosphamide on outcomes in stem cell transplant recipients with myelofibrosis2025
  2. 2Mismatched unrelated and haploidentical transplant with post-transplant cyclophosphamide-based graft versus host disease prophylaxis are effective for myelofibrosis2025
  3. 3Improved Outcomes in Myelofibrosis after Allogeneic Stem-Cell Transplantation in the Era of Ruxolitinib Pretreatment and Intensified Conditioning Regimen—Single-Center Analysis2024 · 6 citations
  4. 4Long-term outcome and risk factors for relapse after allogeneic hematopoietic stem cell transplantation in myelofibrosis: Results from a large multicenter cohort2025
  5. 5Impact of Donor Type on Outcomes After Allogeneic Hematopoietic Cell Transplantation in Myelofibrosis: A Study on Behalf of the Chronic Malignancies Working Party of the EBMT2025 · 6 citations