What question did this study set out to answer?

This research aims to analyze the relationship between activated Tregs and infection rates in chronic lymphocytic leukemia patients.

December 8, 2025BloodOpen Access

Elevated circulating activated FOXP3+ regulatory T cell subset in patients with advanced chronic lymphocytic leukemia as a marker for severe infections during 1000 days of follow-up

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Authors

MDMojca Dreisinger ZRZlatko Roškar MSMatjaz Sever

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Implication

Prospective cohort study shows higher activated Treg levels correlate with increased severe infections in CLL patients, suggesting need for antibiotics.

Key Points

This research aims to analyze the relationship between activated Tregs and infection rates in chronic lymphocytic leukemia patients.
Single-centre prospective cohort study
Included 37 patients with advanced chronic lymphocytic leukemia
Used flow cytometry to analyze T cell subsets
Followed patients during treatment up to 1000 days
Infection rates were analyzed using the log-rank test
58% of patients with high activated Tregs had grade ≥3 infections by day 365
Grade ≥3 infection rate was significantly higher in high aTreg group (0.70/year vs. 0.04/year)
Only one additional serious infection occurred in the low aTreg group during follow-up
5 out of 13 total deaths were due to infections, concentrated among high Treg group
The type of therapy did not significantly affect infection rates.

Cite This Study

Dreisinger et al. (2025) studied this question.

synapsesocial.com/papers/69362f714fa91c937236e1b4 https://doi.org/10.1182/blood-2025-3904

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Implication

Prospective cohort study shows higher activated Treg levels correlate with increased severe infections in CLL patients, suggesting need for antibiotics.

Elevated circulating activated FOXP3+ regulatory T cell subset in patients with advanced chronic lymphocytic leukemia as a marker for severe infections during 1000 days of follow-up

Discussion

Member takes

Implication

Key Points

Cite This Study

Elevated circulating activated FOXP3+ regulatory T cell subset in patients with advanced chronic lymphocytic leukemia as a marker for severe infections during 1000 days of follow-up

Discussion

Member takes

Implication

Key Points

Cite This Study

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