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This research aims to evaluate the relevance and frequencies of suppressive iNKT cell populations in chronic lymphocytic leukaemia (CLL).

Oncology: International Scientific Conference on Medicine and Health Sciences of the University of Latvia, 2026

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This research aims to evaluate the relevance and frequencies of suppressive iNKT cell populations in chronic lymphocytic leukaemia (CLL).
Samples from 60 untreated CLL patients and healthy controls analyzed by multi-colour flow cytometry.
Quantification of iNKTreg and iNKT10 cell populations alongside monocytic myeloid-derived suppressor cells (M-MDSCs).
Evaluation of clinical stage and prognostic markers such as ZAP-70 and CD38. ROC analysis to identify predictive cut-off values.
iNKTreg and iNKT10 cell frequencies were significantly higher in CLL compared to controls, particularly in advanced stages.
Elevated iNKTreg correlated with shorter time to first treatment (TTFT) and were associated with worse prognostic markers like ZAP-70 and CD38.
The frequency of both iNKT subsets exhibited a positive correlation with circulating IDO-expressing M-MDSCs.

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Randomized trial reveals prognostic factors in chronic lymphocytic leukaemia, indicating improved patient care.

Mārcis Leja (2026) studied this question.

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