What question did this study set out to answer?

To analyze survival and clinical outcomes in chronic lymphocytic leukemia across different treatment eras and therapies.

December 8, 2025BloodOpen Access

A decade of progress: A comparative analysis of real-world survival in chronic lymphocytic leukemia across therapeutic eras

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Retrospective cohort study shows improved survival in chronic lymphocytic leukemia with targeted therapies, highlighting treatment era significance.

To analyze survival and clinical outcomes in chronic lymphocytic leukemia across different treatment eras and therapies.
Retrospective cohort study using de-identified patient data from TriNetX
Identified 135,579 patients with chronic lymphocytic leukemia from 2005 to 2023
Compared outcomes between pre-2015, 2015-2020, and post-2020 cohorts
Stratified patients by treatment received: chemoimmunotherapy vs novel targeted therapy
Outcomes assessed using Kaplan-Meier analysis and propensity score matching.
Significant improvement in survival in patients diagnosed after 2015 compared to pre-2015 era
Confirmed higher risk of all-cause mortality in chemoimmunotherapy cohort versus novel targeted therapy cohort
Patients treated with novel therapies had lower relapse rates and better survival outcomes.

Elliott et al. (2025) studied this question.

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Retrospective cohort study shows improved survival in chronic lymphocytic leukemia with targeted therapies, highlighting treatment era significance.