PET/CT parameters as predictors of early progression risk in newly diagnosed multiple myeloma patients eligible for autologous stem cell transplantation
Observational study shows FDG PET/CT metrics predict early progression risk in multiple myeloma, suggesting enhanced treatment strategies.
Key Points
This research aims to evaluate the prognostic value of PET/CT parameters in predicting early progression risk in newly diagnosed multiple myeloma patients eligible for autologous stem cell transplantation.
Observational study with 58 newly diagnosed multiple myeloma patients
Patients received VRd regimen induction therapy
Comparison of PET/CT parameters between early progression and sustained response cohorts
Statistical analyses included Mann–Whitney U test and Fisher's exact test
Median SUVmax of the most active lesion was significantly higher in early progressors (11.61 vs. 7.22, p = 0.0378)
Trends indicated higher rSUV in early-progression cohort (median 3.18 vs. 1.96, p = 0.0909)
Presence of soft-tissue plasmacytomas was more common in early progressors (100% vs. 70%, p = 0.0902)