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December 8, 2025BloodOpen Access

Spatial proteomics of the bone marrow reveals distinct Tumor–Immune niches in smoldering and relapsed myeloma and their remodeling in response to bispecific antibody and CAR-T therapy

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Authors

KFKane FosterDHDaniel Heilpern-MalloryMSMauro Nicollas Oliveira Silvério

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Overview

Spatial proteomics shows distinct immune niches and T cell responses in myeloma, suggesting therapeutic implications for bispecific antibodies.

Key Points

  • This research investigates tumor-immune interactions within the bone marrow microenvironment in myeloma.
  • Analyzed 121 bone marrow biopsies from patients with smoldering and relapsed myeloma.
  • Employed spatial proteomics to map the microenvironment and evaluate treatment responses.
  • Utilized a 32-marker imaging mass cytometry panel and assessed spatial cell-cell interactions.
  • Found distinct differences in immune cell composition between smoldering and relapsed myeloma.
  • Identified higher levels of T cells in smoldering myeloma versus activated T cells in relapsed cases.
  • Showed that robust PC–T cell interactions predict shorter progression-free survival.

Cite This Study

Foster et al. (2025) studied this question.

synapsesocial.com/papers/69362f714fa91c937236e1fchttps://doi.org/10.1182/blood-2025-3921
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