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Assess the impact of regular red blood cell transfusions on height and growth in adolescents with sickle cell disease and short stature.

December 8, 2025Blood

Red blood cell transfusions for adolescent patients with sickle cell disease & short stature: A long term follow up study

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Assess the impact of regular red blood cell transfusions on height and growth in adolescents with sickle cell disease and short stature.
Included adolescent patients with sickle cell disease and short stature receiving transfusion therapy
Measuring height, weight, and body mass index over a long-term follow-up period
Treatment for iron overload managed with deferasirox if serum ferritin was high
Median height increased by 32.0 cm after transfusion therapy (p < 0.025)
Median weight increased by 16.78 kg (p = 0.007)
Patients experienced growth despite starting therapy during late adolescence, with significant improvements observed

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Implication

Long-term results show transfusion therapy improves height and weight in adolescents with sickle cell disease, suggesting effective interventions for growth issues.

Cite This Study

Aleem et al. (2025) studied this question.

synapsesocial.com/papers/69362f744fa91c937236e27b https://doi.org/10.1182/blood-2025-6517

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Implication

Long-term results show transfusion therapy improves height and weight in adolescents with sickle cell disease, suggesting effective interventions for growth issues.

Red blood cell transfusions for adolescent patients with sickle cell disease & short stature: A long term follow up study

Key Points

Discussion

Implication

Cite This Study

Red blood cell transfusions for adolescent patients with sickle cell disease & short stature: A long term follow up study

Key Points

Discussion

Implication

Cite This Study

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