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March 15, 2026Health Science ReportsOpen Access

Assessing Liver and Iron Markers in Steady State Pediatric SCD Patients to Ascertain the Hepatic Consequences of Hemotransfusion: A Case‐Control Study in Ghana

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Authors

JSJohn Agyemang SahSTStephen TwumasiAAAllwell Adofo Ayirebi

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Overview

Case-control study reveals elevated liver enzymes and iron markers in pediatric sickle cell disease patients, suggesting monitoring post-transfusion is essential.

Key Points

  • This research aims to assess the hepatic consequences of hemotransfusion in pediatric patients with sickle cell disease.
  • Case-control study involving 120 children with SCD and 60 without SCD.
  • Participants' sociodemographic details and transfusion history collected via structured questionnaire.
  • Blood samples taken for laboratory analysis of liver and iron markers.
  • Serum iron levels were significantly higher in children with SCD, especially in those with HbSS genotype.
  • Elevated total iron binding capacity, ALT, and GGT levels were found in SCD patients compared to controls.
  • Increased frequency of hemotransfusion correlated with higher serum iron, ferritin, and transferrin saturation levels among SCD patients.

Cite This Study

Sah et al. (2026) studied this question.

synapsesocial.com/papers/69b606d583145bc643d1d1ffhttps://doi.org/10.1002/hsr2.72090
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Iron stores in steady‐state sickle cell disease children accessing care at a sickle cell disease clinic in Kumasi, Ghana: A cross‐sectional study2022 · 13 citations
  2. 2Hepatic Enzyme Abnormalities and Their Association With Hematological Parameters in Sickle Cell Disease: A Case‐Control Study in Cameroon2026
  3. 3Circulating biomarkers associated with pediatric sickle cell disease2024 · 9 citations
  4. 4Hematological and biochemical alterations in school-aged children with sickling cell disorders indicate an elevated risk of liver and cardiovascular diseases2025
  5. 5Full assessment of clinical transfusion support (FACTS): A prospective Study to determine the burden of sickle cell anemia on pediatric blood transfusion use in a malaria-endemic region in Africa2025