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June 13, 2026Health Science ReportsOpen Access

Hepatic Enzyme Abnormalities and Their Association With Hematological Parameters in Sickle Cell Disease: A Case‐Control Study in Cameroon

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Authors

JLJosué Simo LouokdomPAPrisca Tipane AngandjiRTRomaric De Manfouo Tuono

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Overview

Case-control study shows hepatic enzyme abnormalities related to hematological changes in sickle cell disease, indicating significant liver involvement.

Key Points

  • This study examines the frequency of hepatic enzyme abnormalities in patients with sickle cell disease and their association with hematological parameters.
  • Conducted a 4-month case-control study at Bafoussam Regional Hospital involving 167 participants (94 sickle cell disease patients and 73 healthy controls).
  • Blood samples were collected for complete blood counts and biochemical analyses of liver enzymes and albumin levels.
  • Data were analyzed using R software version 4.1.1.
  • ALT levels were significantly higher in patients (median 18.2 U/L) compared to controls (15.1 U/L, p=0.007).
  • 72.3% of patients had elevated AST levels while controls had none (p<0.001).
  • 60% of patients presented with elevated ALP levels versus none in controls (p<0.001).

Cite This Study

Louokdom et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf665faef96ed7f05824ahttps://doi.org/10.1002/hsr2.72649
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  1. 1Evaluation Of Some Haematological Parameters, Liver Enzymes And Bilirubin In Sickle Cell Diseased Patients Attending Federal University Teaching Hospita, Owerri2024
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  3. 3Assessing Liver and Iron Markers in Steady State Pediatric SCD Patients to Ascertain the Hepatic Consequences of Hemotransfusion: A Case‐Control Study in Ghana2026
  4. 4Assessment of Haptoglobin, Creatinine and Novel Markers of AKI in Homozygous and Heterozygous Sickle Cell Disease Patients in Ekiti State.2025
  5. 5Oxidative Stress, Antioxidant Capacity, Dyslipidemia and Cardiovascular Risk in Sickle Cell Disease: A Systematic Review and Meta‐Analysis2026