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December 8, 2025Blood

Full assessment of clinical transfusion support (FACTS): A prospective Study to determine the burden of sickle cell anemia on pediatric blood transfusion use in a malaria-endemic region in Africa

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Authors

KMKathryn E. McElhinneyAKAbigail KincaidCKCharles Drago Kato

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Overview

Prospective study shows high sickle cell anemia prevalence among pediatric transfusion recipients in malaria-endemic regions, indicating need for targeted interventions.

Key Points

  • This research aims to determine the burden of sickle cell anemia on blood transfusion use among children in a malaria-endemic region.
  • Conducted a prospective, cross-sectional study in Jinja, Uganda.
  • Analyzed dry blood spots from pediatric transfusion recipients for HbSS and malaria.
  • Collected data on transfusion indications and recipient demographics.
  • 55% of transfusion recipients had sickle cell anemia, indicative of a significant transfusion burden.
  • Malaria parasitemia was detected in 56% of recipients, primarily caused by Plasmodium falciparum.
  • The majority of children with transfusions also had sickle cell anemia, highlighting the dual burden of disease.

Cite This Study

McElhinney et al. (2025) studied this question.

synapsesocial.com/papers/69362f484fa91c937236d6f9https://doi.org/10.1182/blood-2025-300
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Availability of blood products and transfusion practices in sub-saharan Africa for the management of patients with sickle cell disease: A survey in 16 countries.2025
  2. 2Reducing transfusion utilization for children with sickle cell anemia in sub‐Saharan Africa with hydroxyurea: Analysis from the phase <scp>I</scp>/<scp>II REACH</scp> trial2024 · 6 citations
  3. 3Blood transfusion requirements among children with severe malarial anemia: a cross-sectional study in a second level reference hospital in Burkina Faso2020 · 14 citations
  4. 4A global survey of blood transfusion practices for patients with sickle cell disease2026
  5. 5Subclinical malaria in sickle cell disease in Northern Uganda: prevalence, predictors, and hematologic impact2026