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December 8, 2025Blood

Trends and disparities in ischemic heart disease and anemia-related mortality in adults aged ≥ 65 years in the United States from 1999 to 2023: A CDC wonder database analysis

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Authors

ARAhmed RazaSRSaif RahmanAKAmal Khan

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Overview

Analysis reveals decreasing mortality in ischemic heart disease and anemia for older adults, suggesting disparities remain significant across demographics.

Key Points

  • This research assesses mortality trends related to ischemic heart disease and anemia in older adults from 1999 to 2023 in the U.S.
  • Analyzed CDC WONDER Multiple Cause-of-Death dataset (1999-2023) using ICD-10 codes for ischemic heart disease and anemia.
  • Stratified results by demographic factors, geographic factors, and mortality outcomes.
  • Calculated age-adjusted mortality rates and annual percent change using Joinpoint regression software.
  • 266,717 ischemic heart disease and anemia-related deaths occurred in adults ≥ 65 years from 1999 to 2023.
  • Overall age-adjusted mortality rate decreased from 30.40 in 1999 to 21.69 in 2023.
  • Non-Hispanic Black/African Americans had the highest average mortality rate at 30.79.

Cite This Study

Raza et al. (2025) studied this question.

synapsesocial.com/papers/69362f744fa91c937236e29fhttps://doi.org/10.1182/blood-2025-6457
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Temporal trends and disparities in cardiovascular Disease–Related mortality in older adults with co-morbid anemia from 1999 to 2023 in the United States: A CDC wonder database analysis2025
  2. 2National trends and disparities in mortality involving ischemic heart disease andanemia in the United States, 1999-20232025
  3. 3Trends and disparities in nutritional anemia-related mortality in the elderly in theunited states from 1999 to 2023: A CDC wonder database analysis2025
  4. 4Trends and disparities in anemia and pneumonia-related mortality in the United States from 1999 to 2023: A CDC wonder database analysis2025
  5. 5Trends and disparities in anemia and COPD-related mortality among adults in the United States from 1999 to 2023: A CDC wonder database analysis2025