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December 8, 2025BloodOpen Access

Disparities and reversal of declines: A 22-year analysis of mortality trends in patients with concurrent anemia and heart failure in the United States (1999–2020)

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Authors

MUMuhammad UmerKing Edward Medical UniversityMAMuhammad AhmedShaheed Mohtarma Benazir Bhutto Medical University

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Implication

Analysis reveals increases in mortality for heart failure and anemia in diverse populations, indicating concerning disparities.

Key Points

  • This research examines mortality trends and disparities in patients with heart failure and anemia in the United States over the past 22 years.
  • Used CDC WONDER database for mortality data (1999-2020)
  • Calculated annual crude mortality rates per 100,000 population
  • Applied Joinpoint regression to assess trends and calculate annual percent changes
  • Stratified analyses by sex, race/ethnicity, age, and U.S. census region
  • 47,390 deaths associated with heart failure and anemia during the study period
  • Crude mortality rate increased from 1.25 to 1.84 per 100,000
  • Males exhibited higher mortality than females throughout the years
  • Black individuals experienced the steepest rise in mortality rates
  • Significantly rising mortality rates observed in medium metro and rural areas

Cite This Study

Umer et al. (2025) studied this question.

synapsesocial.com/papers/693624dd4fa91c937236d1abhttps://doi.org/10.1182/blood-2025-6450
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1National trends and disparities in mortality involving ischemic heart disease andanemia in the United States, 1999-20232025
  2. 2A converging crisis: Long-term mortality trends in respiratory failure and anemia inthe United States, 1999–20232025
  3. 3Trends and disparities in ischemic heart disease and anemia-related mortality in adults aged ≥ 65 years in the United States from 1999 to 2023: A CDC wonder database analysis2025
  4. 4Temporal trends and disparities in cardiovascular Disease–Related mortality in older adults with co-morbid anemia from 1999 to 2023 in the United States: A CDC wonder database analysis2025
  5. 5Prevalence and temporal trends of anemia in patients with heart failure2021 · 15 citations