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December 8, 2025Blood

A converging crisis: Long-term mortality trends in respiratory failure and anemia inthe United States, 1999–2023

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Authors

JUJanta UkraniHWHussain WasifSSSabah Siddiqui

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Overview

Analysis reveals rising mortality rates for respiratory failure and anemia in older adults, highlighting racial disparities and urgent healthcare needs.

Key Points

  • This research aims to explore long-term mortality trends related to respiratory failure and anemia in the US.
  • Mortality data were extracted from the CDC WONDER database.
  • ICD-10 codes J96.x and D50–D64 were used for analysis.
  • Age-adjusted mortality rates were calculated per 100,000 population.
  • Trends analyzed using Joinpoint regression for Annual Percent Change and Average Annual Percent Change.
  • Analyses stratified by demographic factors such as sex, race/ethnicity, and age group.
  • A total of 188,978 deaths from respiratory failure and anemia were recorded from 1999 to 2023.
  • The national age-adjusted mortality rate increased from 1.23 to 3.56 per 100,000 from 1999 to 2023.
  • Higher mortality rates were observed among older adults and non-Hispanic Black individuals.
  • Significant regional disparities were noted, with the West having the highest mortality rates.
  • Post-2021, a slight decrease in mortality rates was observed, yet they remain elevated.

Cite This Study

Ukrani et al. (2025) studied this question.

synapsesocial.com/papers/69362f744fa91c937236e2achttps://doi.org/10.1182/blood-2025-6456
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Also Consider

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  1. 1Trends and disparities in anemia and COPD-related mortality among adults in the United States from 1999 to 2023: A CDC wonder database analysis2025
  2. 2Disparities and reversal of declines: A 22-year analysis of mortality trends in patients with concurrent anemia and heart failure in the United States (1999–2020)2025
  3. 3National trends and disparities in mortality involving ischemic heart disease andanemia in the United States, 1999-20232025
  4. 4“trends in anemia and chronic lower respiratory diseases related mortality (1999-2023): A CDC wonder database analysis.”2025
  5. 5Trends and disparities in anemia and pneumonia-related mortality in the United States from 1999 to 2023: A CDC wonder database analysis2025