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December 8, 2025BloodOpen Access

Temporal trends and demographic patterns in Hodgkin and non-Hodgkin lymphoma mortality among u.s. adults: A CDC wonder study

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Authors

RIRehan IshaqueSMSibgha Fawad MemonLALaksh Kumar Ahuja

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Overview

Population-based study reveals declining mortality trends for lymphomas, indicating treatment gaps remain.

Key Points

  • This research analyzes mortality trends for Hodgkin and non-Hodgkin lymphoma in the U.S. over two decades.
  • Retrospective population-based study utilizing CDC WONDER data
  • Analyzed deaths related to Hodgkin and non-Hodgkin lymphoma from 1999 to 2020
  • Used Joinpoint regression to assess mortality trends and average annual percent change (AAPC)
  • ICD codes C81.0-81.9 for Hodgkin lymphoma and C82.0-85.9 for non-Hodgkin lymphoma were employed
  • A total of 35,319 deaths from Hodgkin lymphoma and 557,741 from non-Hodgkin lymphoma were recorded
  • Both types showed significant mortality decline: Hodgkin lymphoma AAPC was -2.79% and non-Hodgkin lymphoma AAPC was -2.10%
  • Mortality trends differed by gender, with males typically experiencing higher rates for both types
  • Mortality decline was particularly pronounced among females for both Hodgkin and non-Hodgkin lymphomas
  • Demographic disparities were noted, with Whites exhibiting higher mortality rates for both Hodgkin and non-Hodgkin lymphomas.

Cite This Study

Ishaque et al. (2025) studied this question.

synapsesocial.com/papers/69362f744fa91c937236e2fdhttps://doi.org/10.1182/blood-2025-8039
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