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Evaluate the prognostic impact of clinicopathologic features and treatment on survival in DLBCL patients.

December 8, 2025BloodOpen Access

Clinicopathologic and treatment influences on diffuse large B-cell lymphoma survival: A 10-year safety-net hospital experience

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Evaluate the prognostic impact of clinicopathologic features and treatment on survival in DLBCL patients.
Retrospective analysis of electronic health records for 75 DLBCL patients from 2013 to 2023.
Measured variables include Charlson Comorbidity Index, International Prognostic Index, and treatment modalities.
Utilized logistic regression and Cox proportional hazards models to analyze predictors of mortality and overall survival.
Older age and high-risk IPI are significant predictors of mortality.
Patients with higher CCI exhibited worse survival outcomes.
Supportive care and single-agent therapy resulted in significantly lower survival rates.

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Retrospective analysis reveals that high-risk ipi and comorbidities predict poor dlbcl survival, indicating tailored treatment needs.

Chen et al. (2025) studied this question.

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