What type of study is this?

This is a Cohort Study study (also classified as: Human Clinical Trial).

What question did this study set out to answer?

This research aims to clarify the impact of adjunctive aspirin on clinical outcomes among APS patients experiencing arterial thrombosis.

December 8, 2025Blood

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This real-world cohort study finds aspirin use increases bleeding risks without reducing mortality in APS patients with arterial events.

This research aims to clarify the impact of adjunctive aspirin on clinical outcomes among APS patients experiencing arterial thrombosis.
Retrospective cohort study utilizing the TriNetX Network.
Included APS patients with arterial thrombosis on warfarin with or without low-dose aspirin.
Defined cohorts matched on demographics and comorbidities using 1:1 propensity score matching.
Outcomes assessed included thrombotic events, bleeding complications, mortality, and healthcare utilization over a 4-year follow-up.
After matching, 2,144 patients were in each cohort, showing increased hazards for bleeding complications in the aspirin group.
Risk of gastrointestinal bleeding increased (HR 1.44, p=0.002) and hemoperitoneum (HR 3.20, p=0.003) in patients taking aspirin.
Higher incidences of ischemic stroke (HR 1.52, p=0.009) and acute myocardial infarction (HR 2.10, p<0.001) were observed in those on aspirin, without improving overall mortality.

Chandra et al. (2025) studied this question.

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