Key result
Warfarin increases major bleeding ~110% vs. aspirin in AF.
Why the study?
Bleeding complications significantly reduce the net effectiveness of warfarin compared to aspirin for stroke prevention in atrial fibrillation, especially in older patients.
Comparison
Warfarin vs aspirin (325 mg daily)
Design
Randomized controlled trial
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Bleeding risk, especially in older AF patients, tempers warfarin's net benefit; leaves open safer antithrombotic strategies.
RCT (n=1,100)
Relative Risk: 2.1 (95% CI 1.1–3.1)
Absolute Event Rate: 2.3% vs 1.1%
p-value: p=.02
A 1996 study conducted an RCT in Atrial fibrillation (n=1,100). Warfarin vs. Aspirin 325 mg daily was evaluated on Major hemorrhages (RR 2.1, 95% CI 1.1 to 3.1, p=.02). Warfarin increased the rate of major bleeding compared to aspirin in patients with atrial fibrillation (2.3% vs 1.1% per year; RR 2.1; 95% CI 1.1-3.1; P=0.02).
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